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Thyroid Hormones as Renal Cell Cancer Regulators
Łukasz Szymański1, Damian Matak2, Ewa Bartnik3
1Department of Oncology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland; Institute of Genetics and Biotechnology, Faculty of Biology, Warsaw University, Pawinskiego 5a, 02-106 Warsaw, Poland; Department of Microwave Safety, Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, Poland.
Journal of Signal Transduction
|April 2, 2016
Summary
Thyroid hormone influences cancer progression. This review focuses on how thyroid hormone and its receptors regulate renal cell carcinoma, considering genomic changes and splicing.
Area of Science:
- Endocrinology
- Oncology
- Molecular Biology
Background:
- Thyroid hormone is a key regulator in cancer development and metastasis.
- Genomic alterations and alternative splicing can modulate thyroid hormone receptor activity.
- The mechanism of thyroid hormone action varies significantly across different cancer types.
Purpose of the Study:
- To review the role of thyroid hormone and its receptors in regulating renal cell carcinoma (RCC).
- To explore how genomic changes and alternative splicing impact thyroid hormone signaling in RCC.
Main Methods:
- Literature review of studies on thyroid hormone, its receptors, and renal cell carcinoma.
- Analysis of mechanisms underlying thyroid hormone action in cancer.
- Examination of the interplay between genomic alterations, splicing, and thyroid hormone signaling in RCC.
Main Results:
- Thyroid hormone and its receptors play a distinct regulatory role in renal cell carcinoma.
- Genomic instability and alternative splicing are identified as factors influencing thyroid hormone receptor function in RCC.
- The specific mechanisms of thyroid hormone action in RCC are complex and cancer-type dependent.
Conclusions:
- Thyroid hormone and its receptors are significant regulators in the context of renal cell carcinoma.
- Understanding these regulatory roles is crucial for potential therapeutic strategies in RCC.
- Further research into the molecular mechanisms is warranted to fully elucidate the thyroid hormone's impact on RCC progression.
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