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Uric acid and risk of periprocedural myocardial infarction in patients undergoing percutaneous coronary intervention

Monica Verdoia, Alon Schaffer, Lucia Barbieri

    Diabetes/Metabolism Research and Reviews
    |May 16, 2014
    PubMed

    Insights

    Serum uric acid levels do not predict periprocedural myocardial infarction in patients undergoing percutaneous coronary intervention. This large study found no association between uric acid and myocardial infarction risk after the procedure.

    Area of Science:

    • Cardiology
    • Biomarkers
    • Interventional Cardiology

    Background:

    • Periprocedural myocardial infarction (MI) is a complication of percutaneous coronary intervention (PCI).
    • The predictive role of biomarkers for periprocedural MI remains unclear.
    • Serum uric acid is linked to inflammation, thrombosis, and adverse outcomes post-PCI.

    Purpose of the Study:

    • To evaluate the association between serum uric acid levels and periprocedural myocardial infarction in patients undergoing PCI.
    • To determine if uric acid can serve as a predictive biomarker for MI following PCI.

    Main Methods:

    • A study of 1272 consecutive patients undergoing PCI.
    • Measurement of myonecrosis biomarkers (troponin I, creatine kinase-MB) 8-48 hours post-PCI.
    • Definition of periprocedural myonecrosis and myocardial infarction based on biomarker thresholds.

    Main Results:

    • Serum uric acid levels were associated with various clinical and laboratory parameters, including age, comorbidities, and renal function.
    • Serum uric acid was inversely related to lesion complexity and coronary thrombus.
    • No significant association was found between serum uric acid levels and the risk of periprocedural myocardial infarction or myonecrosis.

    Conclusions:

    • This study is the first large-scale investigation to demonstrate that serum uric acid is not associated with an increased risk of periprocedural myocardial infarction.
    • Findings suggest serum uric acid is not a reliable predictor of periprocedural MI in patients undergoing PCI.
    Abstract

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