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Related Concept Videos

Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

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Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
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Issues And Trends In Healthcare Delivery System01:29

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The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
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Pharmacogenetics and Pharmacogenomics: Overview01:29

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Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Related Experiment Video

Updated: Apr 29, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
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Genomics in primary care practice.

Kathryn Teng1, Louise S Acheson2

  • 1Internal Medicine, Center for Personalized Healthcare (Cleveland Clinic), 9500 Euclid Avenue, NE5-203, Cleveland, OH 44195, USA.

Primary Care
|May 17, 2014
PubMed
Summary
This summary is machine-generated.

Genomic information, including family history and ancestry, offers probabilistic insights for personalized preventive care in healthy adults. This data highlights modifiable risk factors for common diseases and inherited conditions.

Keywords:
AncestryFamily health historyGenomicPreventive carePrimary careValue

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Area of Science:

  • Genomics
  • Preventive Medicine
  • Personalized Healthcare

Background:

  • Family health history is a key genomic predictor for common, multifactorial diseases.
  • Genomic data can indicate inherited susceptibility to specific cancers or other conditions.
  • Bloodline ancestry and shared environmental factors are significant predictors of disease states.

Purpose of the Study:

  • To discuss the clinical utility of genomic information for personalized preventive care.
  • To explore the role of family history and ancestry in predicting disease risk.
  • To emphasize the probabilistic nature of genomic information and its application in risk modification.

Main Methods:

  • Analysis of family health history patterns.
  • Evaluation of bloodline ancestry data.
  • Consideration of shared environmental factors.

Main Results:

  • Family history is the most applicable genomic predictor for common diseases.
  • Genomic analyses provide probabilistic, not deterministic, risk information.
  • Family history can identify modifiable behavioral, social, or cultural risk factors.

Conclusions:

  • Genomic information, particularly family history, is valuable for personalized preventive strategies.
  • Understanding genetic predispositions and environmental influences allows for targeted disease prevention.
  • Probabilistic risk assessment empowers individuals to modify behaviors and mitigate health risks.