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Related Experiment Video

Updated: Apr 29, 2026

Noninvasive Electrocardiography in the Perinatal Mouse

Noninvasive Electrocardiography in the Perinatal Mouse

Published on: June 12, 2020

Introducing WISECONDOR for noninvasive prenatal diagnostics.

Roy Straver¹, Erik A Sistermans, Marcel J T Reinders

¹Delft Bioinformatics Lab, Delft University of Technology, Mekelweg 4, 2628 CD Delft, The Netherlands.

Expert Review of Molecular Diagnostics

|May 17, 2014

Summary

This summary is machine-generated.

Noninvasive prenatal testing now offers improved detection of fetal chromosome abnormalities. A new tool, WISECONDOR, enables cost-effective screening using next-generation sequencing, enhancing prenatal diagnosis.

Keywords:

chromosomal aberrations clinical practice fetal DNA next generation sequencing noninvasive prenatal diagnostics

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Area of Science:

Genetics
Molecular Biology
Obstetrics

Background:

Noninvasive prenatal testing (NIPT) screens for fetal chromosome abnormalities using cell-free fetal DNA from maternal blood.
Next-generation sequencing (NGS) is a key technology in modern prenatal diagnosis.

Purpose of the Study:

To introduce WISECONDOR, a novel tool for detecting copy number aberrations in prenatal screening.
To evaluate the effectiveness and cost-efficiency of WISECONDOR in noninvasive prenatal testing.

Main Methods:

Utilized next-generation sequencing (NGS) for shallow sequencing of fetal DNA in maternal blood.
Employed the WIthin SamplE COpy Number aberration DetectOR (WISECONDOR) algorithm for copy number aberration detection.

Main Results:

WISECONDOR achieves a resolution comparable to traditional karyotyping.
The method is cost-effective due to its requirement for only shallow sequencing.

Conclusions:

WISECONDOR represents a significant advancement in noninvasive prenatal testing.
This technology enhances the information available to expectant parents about fetal well-being and necessitates adaptation in clinical genetics laboratories for NGS integration.