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[A meta-analysis on the relations between Helicobacter pylori infection and chronic urticaria]
Lude Tang1, Yanjun Zhang1, Xiaomeng Gao1
1Department of Microbiology, Harbin Medical University, Harbin 150081, China.
Objective:
To investigate the relationship between Helicobacter pylori (HP) infection and the development of chronic urticaria.
Methods:
Published case-control studies which concerned HP infection related chronic urticaria were searched in Wanfang, CNKI, CQVIP Chinese databanks and PubMed. Meta-analysis was applied to analyze the pooled odds ratio (OR) and 95% confidence interval (CI).
Results:
37 studies which comprised 2 909 cases of chronic urticaria and 1 873 persons served as controls were enrolled. When compared with the controls, HP infection significantly increased the risk of chronic urticaria development with a pooled OR of 3.20 (95% CI: 2.31-4.43). Results from Meta-regression analyses showed that the distribution of residential areas and detection method being used were potential influential factors.
Conclusion:
HP infection seemed to be associated with an increased risk of developing the chronic urticaria.
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