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Updated: Apr 29, 2026

Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle
Published on: March 5, 2019
PRDM Proteins: Molecular Mechanisms in Signal Transduction and Transcriptional Regulation
Erika Di Zazzo1, Caterina De Rosa2, Ciro Abbondanza3
1Department of Medicine and health sciences, University of Molise, via De Sanctis snc, Campobasso 86100, Italy. erika.dizazzo@unimol.it.
Abstract:
PRDM (PRDI-BF1 and RIZ homology domain containing) protein family members are characterized by the presence of a PR domain and a variable number of Zn-finger repeats. Experimental evidence has shown that the PRDM proteins play an important role in gene expression regulation, modifying the chromatin structure either directly, through the intrinsic methyltransferase activity, or indirectly through the recruitment of chromatin remodeling complexes. PRDM proteins have a dual action: they mediate the effect induced by different cell signals like steroid hormones and control the expression of growth factors. PRDM proteins therefore have a pivotal role in the transduction of signals that control cell proliferation and differentiation and consequently neoplastic transformation. In this review, we describe pathways in which PRDM proteins are involved and the molecular mechanism of their transcriptional regulation.
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