Acute Effect of High-Intensity Eccentric Exercise on Vascular Endothelial Function in Young Men
Youngju Choi1, Nobuhiko Akazawa, Asako Zempo-Miyaki
11Department of Sports Medicine, Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan; 2Faculty of Medicine, University of Tsukuba, Ibaraki, Japan; and 3Division of Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
Journal of Strength and Conditioning Research
|May 17, 2014
Summary
High-intensity eccentric exercise acutely increases arterial stiffness and impairs vascular endothelial function in young men. This exercise reduces endothelium-dependent vasodilation, a key factor in cardiovascular health.
Area of Science:
- Exercise Physiology
- Cardiovascular Health
- Vascular Biology
Background:
- Increased central arterial stiffness is a significant independent risk factor for cardiovascular disease.
- Existing research on the impact of high-intensity resistance exercise on vascular endothelial function and arterial stiffness presents conflicting findings.
- Understanding the acute effects of eccentric exercise on vascular health is crucial for cardiovascular disease prevention strategies.
Purpose of the Study:
- To investigate the acute effects of high-intensity eccentric exercise on vascular endothelial function.
- To assess the impact of this exercise on central arterial stiffness.
- To examine changes in endothelium-dependent vasodilation and vasoconstriction.
Main Methods:
- Seven healthy, sedentary young men performed maximal eccentric elbow flexor exercise.
- Measurements of carotid arterial compliance, brachial artery flow-mediated dilation (FMD), and low-flow-mediated constriction (L-FMC) were taken before and 45 minutes post-exercise.
- Analysis included correlations between changes in arterial stiffness and endothelial function parameters.
Main Results:
- Eccentric exercise led to a significant decrease in carotid arterial compliance and a significant increase in the β-stiffness index.
- Brachial artery FMD was significantly reduced post-exercise, indicating impaired endothelium-dependent vasodilation.
- No significant changes were observed in brachial artery L-FMC, suggesting vasoconstriction function remained unaffected.
Conclusions:
- Acute high-intensity eccentric exercise demonstrably increases central arterial stiffness in young men.
- This increase in arterial stiffness is associated with a reduction in endothelial function, specifically impaired vasodilation.
- The findings highlight a potential cardiovascular risk associated with acute high-intensity eccentric exercise, mediated by reduced vasodilation.
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