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In situ forming implants for periodontitis treatment with improved adhesive properties
M P Do1, C Neut2, E Delcourt3
1University of Lille, College of Pharmacy, Lille, France; INSERM U 1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France.
Summary
New in situ forming implants improve periodontitis treatment by enhancing adhesion and drug delivery. These novel poly(lactic-co-glycolic acid) implants offer better retention and controlled release of doxycycline hyclate for effective antimicrobial action.
Area of Science:
- Biomaterials Science
- Periodontology
- Drug Delivery Systems
Background:
- Local periodontitis treatment faces challenges with implant adhesion and retention.
- Uncertainty in implant residence time affects drug exposure and treatment efficacy.
Purpose of the Study:
- To develop novel in situ forming implants with improved adhesion and controlled drug release for periodontitis treatment.
- To enhance the stickiness and deformability of poly(lactic-co-glycolic acid)-based implants.
Main Methods:
- Incorporation of plasticizers (acetyltributyl citrate, dibutyl sebacate) and adhesive polymers (cellulose derivatives).
- Formulation of implants from N-methyl pyrrolidone-based liquid precursors.
- Evaluation of antimicrobial activity using the agar well diffusion method with Streptococcus strains.
Main Results:
- Addition of plasticizers and polymers significantly increased implant stickiness.
- Maintained good plastic deformability and tunable drug release profiles.
- Demonstrated effective antimicrobial activity against periodontitis-associated Streptococcus strains.
Conclusions:
- Novel in situ forming implants offer a promising solution for periodontitis treatment by overcoming adhesion limitations.
- The developed implants provide enhanced retention, controlled drug release, and effective antimicrobial properties.
