Related Experiment Video
Updated: Apr 29, 2026
10:27
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
23.9K
Subclinical celiac disease and gluten sensitivity
Mohammad Rostami Nejad1, Sabine Hogg-Kollars2, Sauid Ishaq3
1Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Gastroenterology and Hepatology From Bed to Bench
|May 17, 2014
Summary
Atypical celiac disease (CD) presentations are common. Simplifying terminology and applying gluten-free diets (GFD) to all CD forms, including atypical ones, can improve patient care.
Area of Science:
- Gastroenterology
- Immunology
- Clinical Medicine
Background:
- Atypical presentations are the most frequent form of celiac disease (CD).
- Existing terminologies like latent, silent, and potential CD contribute to clinical confusion due to varied definitions.
- Advances in understanding non-celiac gluten sensitivity necessitate clearer CD classification.
Purpose of the Study:
- To propose simplified terminology for atypical celiac disease.
- To advocate for a consistent gluten-free diet (GFD) approach across all CD manifestations.
- To reduce diagnostic and therapeutic uncertainty for clinicians and patients.
Main Methods:
- Review of current literature on celiac disease and non-celiac gluten sensitivity.
- Analysis of clinical and pathological behaviors associated with different CD presentations.
- Comparative assessment of diagnostic and therapeutic strategies.
Main Results:
- The terms 'subclinical' and 'atypical' may offer clearer distinctions than 'silent' and 'potential/latent' CD.
- Evidence supports a lower threshold for initiating a GFD in non-celiac gluten sensitivity.
- A unified GFD strategy is beneficial for all forms of CD.
Conclusions:
- Adopting simplified terminology ('subclinical' and 'atypical') can enhance understanding of celiac disease.
- A gluten-free diet (GFD) is recommended for all recognized forms of celiac disease.
- Standardized terminology and treatment protocols are crucial for optimal celiac disease management.
Related Concept Videos
01:25Inflammatory Bowel Disease III: Crohn's Disease
31
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
31
01:30Other Disorders of Digestive System
1.7K
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
1.7K
01:25Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
17
Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated...
17
01:30Inflammatory Bowel Disease II: Crohn's Disease
1.6K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.6K
01:27Glucose Transporters
15.2K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
15.2K
01:24Chronic Pancreatitis I: Introduction
906
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
906