Related Experiment Video
Updated: Apr 29, 2026
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
Microscopic Enteritis; clinical features and correlations with symptoms
Touran Shahraki1, Kamran Rostami2, Mansour Shahraki3
1Department of Pediatrics, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Aim:
To assess the clinical characteristic of CD as well as correlation of symptoms and the degrees of intestinal mucosal lesions in Iranian children.
Background:
Microscopic Enteritis (Marsh 0-II) is associated with malabsorption.
Patients And Methods:
From August 2005 to September 2009, 111 cases with malabsorption and classical gastrointestinal symptoms were evaluated.
Results:
The mean (±SD) age of children with CD was 4.9±3.5 years (range, 6 month - 16 years) and the mean duration of symptoms was 8 ± 20.5 months. 50 cases (45%) were female and 61 cases (55%) were male. The most common clinical presentation was failure to thrive in 72%, chronic diarrhea in 65.8% and Iron deficiency anemia in 59.5%. Sensitivity of EMA was 100% in patients with Marsh IIIb and Marsh IIIc. EMA was also positive in 77% of cases with Marsh 0, 18% in Marsh I, 44% in Marsh II and 81.8% in patients with Marsh IIIa.
Conclusion:
Histopathology did not reflect the severity of gluten sensitivity. This would suggest that the degree of intestinal mucosal damage might not be a reliable prognostic factor. Significant symptoms can be present with minor histological change on biopsy.
Insights
In Iranian children with celiac disease (CD), histopathology did not correlate with gluten sensitivity severity. Significant symptoms can occur even with minor intestinal mucosal damage.
Area of Science:
- Pediatric Gastroenterology
- Celiac Disease Research
- Gastrointestinal Pathology
Background:
- Microscopic enteritis (Marsh 0-II) is linked to malabsorption.
- Celiac disease (CD) diagnosis relies on clinical presentation and histopathology.
- Understanding the correlation between symptoms and mucosal damage is crucial for CD management.
Purpose of the Study:
- To evaluate clinical characteristics of celiac disease in Iranian children.
- To investigate the relationship between symptoms and the extent of intestinal mucosal lesions in pediatric CD patients.
- To assess the reliability of histopathology as a prognostic factor for gluten sensitivity.
Main Methods:
- A cohort of 111 Iranian children diagnosed with malabsorption and gastrointestinal symptoms were evaluated between August 2005 and September 2009.
- Clinical data, including age, gender, duration of symptoms, and presenting symptoms, were collected.
- Histopathological findings (Marsh classification) and endomysial antibody (EMA) sensitivity were analyzed in relation to clinical presentation.
Main Results:
- The most frequent symptoms were failure to thrive (72%), chronic diarrhea (65.8%), and iron deficiency anemia (59.5%).
- Endomysial antibody (EMA) sensitivity was 100% in Marsh IIIb and IIIc classifications.
- EMA positivity varied across Marsh classifications, indicating potential discrepancies between histological findings and antibody status.
Conclusions:
- Histopathological findings in pediatric celiac disease may not accurately reflect the severity of gluten sensitivity.
- The degree of intestinal mucosal damage (Marsh classification) might not be a reliable prognostic indicator for CD.
- Clinically significant symptoms can be present despite minor histological changes on intestinal biopsy, highlighting the complexity of CD presentation.
More Related Videos
15:49Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
Published on: October 16, 2013
09:50Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice
Published on: February 11, 2019
Related Concept Videos
01:20Inflammatory Bowel Disease IV: Clinical Manifestations
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:20Inflammatory Bowel Disease II: Ulcerative Colitis
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
01:26Inflammatory Bowel Disease I: Introduction