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Enteroaggregative Escherichia coli, a heterogenous, underestimated and under-diagnosed E. coli pathotype in Iran

Anis Jafari1, Mohammad Mehdi Aslani2, Saeid Bouzari1

  • 1Molecular Biology Unit, Pasteur Institute of Iran, Tehran, Iran ; Escherichia coli Reference Laboratory, Molecular Biology Unit, Pasteur Institute of Iran, Tehran, Iran.

Gastroenterology and Hepatology From Bed to Bench
|May 17, 2014
PubMed

Keywords:
E. coli pathotypeEnteroaggregative Escherichia coliEscherichia coliHeterogeneity

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Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
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