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Inflammatory Bowel Disease II: Crohn's Disease

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Gastritis-II: Pathophysiology

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
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[Gastrointestinal features in systemic sclerosis].

M Stelle, C Chizzolini

Revue Medicale Suisse

|May 20, 2014

Summary

This summary is machine-generated.

Systemic sclerosis (SSc) frequently impacts the gastrointestinal tract (GIT), causing issues from the esophagus to the anus. Management focuses on symptom relief for this rare autoimmune disease.

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Area of Science:

Gastroenterology
Rheumatology
Autoimmune Diseases

Context:

Systemic sclerosis (SSc) is a rare autoimmune disease characterized by vasculopathy, fibrosis, and autoimmunity.
Gastrointestinal tract (GIT) involvement is a common and significant complication in SSc patients.
SSc can affect any part of the GIT, from the esophagus to the anorectal region.

Purpose:

To review the common manifestations of gastrointestinal tract involvement in Systemic Sclerosis.
To highlight the clinical impact and complications of GIT involvement in SSc.
To discuss current therapeutic strategies for managing GIT symptoms in SSc.

Summary:

Esophageal involvement is most common, leading to reflux, erosive esophagitis, and Barrett's esophagus.
Gastric issues include hemorrhage from gastric antral vascular ectasia (GAVE).
Intestinal and anorectal complications encompass malabsorption, pseudo-obstruction, bacterial overgrowth, incontinence, and rectal prolapse.

Impact:

Gastrointestinal tract involvement significantly increases morbidity and mortality in Systemic Sclerosis.
Effective management of GIT symptoms is crucial for improving the quality of life in SSc patients.
Understanding these complications aids in developing targeted therapeutic approaches for SSc-associated GIT disease.