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Updated: Apr 29, 2026

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
Protease inhibitor monotherapy is not associated with increased viral replication in lymph nodes
David Vinuesa1, Jorge Parra-Ruiz, Natalia Chueca
1aService of Infectious Diseases bService of Microbiology, Hospital Universitario San Cecilio, Granada, Spain.
Abstract:
There are concerns about residual viremia in sanctuary sites among patients on protease inhibitor monotherapy, so we aimed to study viro-immunological parameters in tonsil's lymphoid tissue of patients on highly active antiretroviral therapy (HAART) and on protease inhibitor monotherapy. Despite fully suppressed serum HIV viral load, we found viral replication in both groups; in addition, more patients had detectable proviral DNA among those on HAART, compared to those on protease inhibitor monotherapy (P = 0.08), supporting the absence of a deleterious effect of protease inhibitor monotherapy.
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