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Related Concept Videos

Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
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[Multiple primary cutaneous plasmacytoma].

N Malissen1, C Fabre1, J-M Joujoux2

  • 1Service de dermatologie, CHU de Nîmes, place du Pr R. Debré, 30029 Nîmes cedex 9, France.

Annales De Dermatologie Et De Venereologie
|May 20, 2014
PubMed
Summary
This summary is machine-generated.

Primary cutaneous plasmacytoma (PCP) is a rare B-cell lymphoma. In an indolent case, therapeutic abstention led to no progression over 4 years, challenging standard chemotherapy protocols.

Keywords:
AbstentionPlasmocytome cutané multiplePrimary cutaneous plasmacytomaTherapeutic abstentionTraitementTreatment

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Area of Science:

  • Dermatology
  • Oncology
  • Hematology

Background:

  • Primary cutaneous plasmacytoma (PCP) is a rare cutaneous B-cell lymphoma.
  • Characterized by clonal plasma cell proliferation in the skin.
  • Multiple PCPs are exceptionally rare.

Observation:

  • A 51-year-old male presented with widespread, gradually developing erythematous papulonodular lesions over two years.
  • Histologic and immunohistochemical analyses confirmed cutaneous plasmacytoma.
  • Staging confirmed the primary nature of the disease without functional impairment.

Findings:

  • Therapeutic abstention was chosen due to the indolent nature and lack of symptoms.
  • No disease progression was observed during four years of regular monitoring.
  • This case suggests that certain indolent PCP forms may not require immediate chemotherapy.

Implications:

  • Challenges the conventional treatment approach for primary cutaneous plasmacytoma.
  • Highlights the potential for watchful waiting in specific indolent cases.
  • May lead to revised management strategies for rare cutaneous lymphomas.