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Updated: Apr 29, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Value judgments for priority setting criteria in genetic testing: a discrete choice experiment.
Franziska Severin1, Wolfgang Hess2, Jörg Schmidtke3
1Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Health Economics and Health Care Management (IGM), Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.
Prioritizing genetic tests involves balancing disease severity, test benefits, and costs. Stakeholder values differ, highlighting the need for consistent, evidence-based decision-making in genetic test prioritization.
Area of Science:
- Medical Genetics
- Health Economics
- Bioethics
Background:
- Increasing genetic test availability necessitates fair prioritization strategies in healthcare.
- European healthcare systems face cost containment pressures, intensifying the need for genetic test prioritization.
Purpose of the Study:
- To assess stakeholder value judgments on genetic test prioritization criteria.
- To inform policy debates and enhance consistency in prioritizing genetic tests.
Main Methods:
- A discrete-choice experiment was employed with 594 participants.
- Standard logit and mixed-effects models were used to analyze attribute preferences.
Main Results:
- Proven medical benefit, high disease risk, and low test costs were most valued.
- Significant differences in prioritization rankings were observed between clinical geneticists and other stakeholders.
Conclusions:
- Determined priority weights can guide policy and improve decision-making consistency in genetic test prioritization.
- Further stakeholder deliberation is recommended for optimal application in practice.
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