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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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Related Experiment Video

Updated: Apr 29, 2026

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

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Long noncoding RNAs and prostate carcinogenesis: the missing 'linc'?

Anna L Walsh1, Alexandra V Tuzova2, Eva M Bolton1

  • 1Prostate Molecular Oncology Research Group, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland; Department of Urology, St. James's Hospital, Dublin, Ireland.

Trends in Molecular Medicine
|May 20, 2014
PubMed
Summary
This summary is machine-generated.

Long noncoding RNAs (lncRNAs) are key in prostate cancer, influencing progression and metastasis. Prostate-specific lncRNAs show promise as diagnostic biomarkers for early detection and targeted therapies.

Keywords:
androgen receptorchromatinlncRNAsprostate cancer

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Related Experiment Videos

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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
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Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Long noncoding RNAs (lncRNAs) play increasingly recognized roles in cancer biology.
  • Aberrant lncRNA expression is linked to prostate cancer progression and metastasis.

Purpose of the Study:

  • To review the mechanisms of action of lncRNAs in prostate carcinogenesis.
  • To explore the clinical utility of lncRNAs as biomarkers in prostate cancer.

Main Methods:

  • Literature review of studies on lncRNA function in prostate cancer.
  • Analysis of lncRNA involvement in oncogenic pathways, including chromatin modification and gene regulation.

Main Results:

  • lncRNAs influence prostate cancer cell proliferation and metastasis via chromatin looping, androgen receptor interaction, and DNA repair.
  • Prostate-specific lncRNAs like PCA3, PCGEM1, and PCAT1 are potential diagnostic and prognostic biomarkers.

Conclusions:

  • lncRNAs are critical regulators in prostate cancer development and progression.
  • Prostate-specific lncRNAs offer significant potential for clinical applications in diagnosis and therapy.