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Published on: May 7, 2019
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Central Motor Conduction Time and diffusion tensor imaging metrics in children with complex motor disorders
Daniel E Lumsden1, Verity McClelland2, Jonathan Ashmore3
1Complex Motor Disorder Service, Evelina Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, UK; Rayne Institute, King's College London, UK.
Summary
Diffusion Tensor Imaging (DTI) metrics did not correlate with Central Motor Conduction Time (CMCT) in children with motor disorders. DTI and CMCT offer complementary insights for clinical assessment.
Area of Science:
- Neuroimaging
- Neurophysiology
- Pediatric Neurology
Background:
- Complex motor disorders in children present diagnostic challenges.
- Diffusion Tensor Imaging (DTI) and Central Motor Conduction Time (CMCT) are potential biomarkers.
Purpose of the Study:
- To investigate correlations between DTI metrics and CMCT in pediatric complex motor disorders.
- To assess the utility of DTI and CMCT in clinical evaluation.
Main Methods:
- 49 children evaluated for Deep Brain Stimulation (DBS) underwent CMCT assessment.
- Tract-Based Spatial Statistics (TBSS) analyzed DTI metrics comparing normal and abnormal CMCT groups and explored correlations.
Main Results:
- No significant correlations were found between DTI metrics and CMCT.
- No differences in DTI metrics were observed between children with normal and abnormal CMCT.
Conclusions:
- Current DTI metrics may not fully explain the tissue properties influencing CMCT.
- DTI and CMCT provide complementary information for assessing children with complex motor disorders.
