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Published on: August 6, 2020
An epidemiological study investigating the relationship between chorangioma and infantile hemangioma
Alessia Selmin1, Francesca Foltran2, Silvia Chiarelli3
1Department for Women and Neonatal Care, Abano Terme General Hospital, Abano, PD, Italy.
Insights
Infantile hemangioma (IH) incidence is significantly higher in infants born with placental chorangioma compared to the general population. This suggests a potential link between these conditions that warrants further investigation.
Area of Science:
- Obstetrics and Gynecology
- Pediatric Pathology
- Neonatology
Background:
- Placental chorangiomas are rare tumors with an unknown association with infantile hemangiomas (IH).
- Previous research has not established a clear link between chorangiomas and the incidence of IH.
Purpose of the Study:
- To determine if infants with placental chorangiomas have a higher incidence of infantile hemangiomas (IH) than the general population.
- To investigate the potential relationship between placental chorangioma and IH.
Main Methods:
- Retrospective analysis of placental chorangioma diagnoses from 2004-2010.
- Collection of maternal and infant data, including follow-up interviews to identify IH cases.
- Comparison of IH incidence with national/regional data and literature estimates.
Main Results:
- Thirty-eight placental chorangiomas were identified.
- 55% of infants born with chorangioma-affected placentas developed IH, a significantly higher rate than the general population.
- Increased incidence of stillbirth, preterm birth, and low birth weight was also observed.
Conclusions:
- A significantly higher incidence of infantile hemangioma (IH) was observed in infants with placental chorangiomas.
- The findings suggest a potential association between placental chorangioma and IH.
- Further prospective studies are recommended to confirm this association.
Objectives:
This study aimed to verify whether the infantile hemangioma (IH) incidence in children whose placentas showed a chorangioma is higher than in the general population, thus addressing the hypothesized relationship between chorangioma and IH.
Methods:
All chorangioma diagnoses by the 1st Service of Pathology, University of Padova in 2004-2010, based on the analysis of placentas sent by the Department of Gynecological Sciences and Human Reproduction (University of Padova), were identified. Demographic, anamnestic and clinical data were collected from the mothers and newborns; mothers and pediatricians were interviewed by telephone within 1 year after birth to verify if any IH appeared. The incidence rates of IH and other adverse events (IUGR, preterm delivery, cesarean section, stillbirth) were compared with national and regional data, when available, or with estimates from the scientific literature.
Results:
Thirty-eight chorangioma diagnoses were found. Of 33 infants born with a placenta affected by chorangioma, 18 infants had IH. The IH incidence recorded in our series (55%) was significantly higher than that recorded in national and regional surveys and in the scientific literature. Similar findings have been observed for the incidence of stillbirth, preterm birth and low birth weight incidence.
Conclusions:
The IH incidence observed in our series appears to be significantly higher than that recorded among the general population, suggesting that an association between placental chorangioma and IH could exist which should be further verified in prospective studies.
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