[Modern approach to breast cancer diagnostics]

Area of Science:

• Oncology and Diagnostics
• Biochemistry and Molecular Biology
• Medical Technology

Context:

• Early detection of breast cancer is crucial for improving patient outcomes and survival rates.
• Current diagnostic methods face limitations in sensitivity and specificity, necessitating novel approaches.
• The integration of multi-omics data presents a significant opportunity for personalized cancer diagnostics.

Purpose:

• To review and classify modern instrumental, microscopic, and molecular techniques for early breast cancer diagnosis.
• To evaluate the analytical performance of these diagnostic approaches.
• To assess the potential clinical utility and future perspectives of these methods in practice.

Summary:

• Literature data on advanced instrumental, microscopic, and molecular (metabolomics, proteomics, genetics, epigenetics) methods for early breast cancer diagnostics were classified.
• The analytical performance of these techniques was assessed.
• The perspectives for their application in clinical practice were evaluated.

Impact:

• Provides a comprehensive overview of cutting-edge diagnostic technologies for breast cancer.
• Highlights the potential of molecular and multi-omics approaches in early cancer detection.
• Informs researchers and clinicians about the current state and future directions in breast cancer diagnostics.