[Oral contraceptive agents and the fibrinolytic system]

The study included 35 women at the age of 20 to 38 years, using oral contraceptive drugs for a period of two to ten years. Changes in the activity of plasmin and alpha 2 antiplasmin were examined in the blood plasma. The study included three phases of the menstrual cycle (7-14-21 day) in 25 women. Kinetic methods with chromogenic substrates were used as Statchrom PLC was used for plasmin, but Chromosim AP (modification of Kamenov)--for alpha 2 antiplasmin. The applied contraceptive hormonal preparations were Gravistat 250 and Nonovlon. The mean activity of plasmin was x = 108.3%, but of alpha 2 antiplasmin x = 106.3%. Both values did not differ from that of the reference group (p greater than 0.05). The established slight tendency to a reduction in the activity of both examined parameters could be due to differences in the hormonal content of the preparations as well as to individual fluctuations of the hormonal cycle in the investigated patients. The two proteins participate in the acute reaction of the organism and change their concentrations quickly and this fact should be taken into consideration as well.