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Updated: Apr 29, 2026
Optical Trapping of Plasmonic Nanoparticles for In Situ Surface-Enhanced Raman Spectroscopy Characterizations
Published on: June 23, 2022
Spectral Characterization and Intracellular Detection of Surface-Enhanced Raman Scattering (SERS)-Encoded Plasmonic
Hsiangkuo Yuan1, Andrew M Fales1, Christopher G Khoury1
1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA ; Fitzpatrick Institute for Photonics, Duke University, Durham, NC 27708, USA.
Abstract:
Plasmonic gold nanostars offer a new platform for Surface-Enhanced Raman Scattering (SERS). However, due to the presence of organic surfactant on the nanoparticles, SERS characterization and application of nanostar ensembles in solution have been challenging. Here we applied our newly developed surfactant-free nanostars for SERS characterization and application. The SERS enhancement factors (EF) of silver spheres, gold spheres and nanostars of similar sizes and concentration were compared. Under 785 nm excitation, nanostars and silver spheres have similar EF, and both are much stronger than gold spheres. Having plasmon matching the incident energy and multiple "hot spots" on the branches bring forth strong SERS response without the need to aggregate. Intracellular detection of silica-coated SERS-encoded nanostars was also demonstrated in breast cancer cells. The non-aggregated field enhancement makes the gold nanostar ensemble a promising agent for SERS bioapplications.
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