Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Apr 29, 2026

Fabrication of Carbon-Based Ionic Electromechanically Active Soft Actuators
14:42

Fabrication of Carbon-Based Ionic Electromechanically Active Soft Actuators

Published on: April 25, 2020

10.2K

Evaluating and modifying Johanson's rolling model to improve its predictability.

Mingda Bi1, Fernando Alvarez-Nunez1, Francisco Alvarez1

  • 1Formulation Group, Pharmaceutical R&DAmgen IncThousand OaksCalifornia91320.

Journal of Pharmaceutical Sciences
|May 21, 2014
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antioxidant and Cytoprotective Effects of Chilean Macroalgae Against Oxidative Stress-Induced Damage in Gastric Epithelial Cells.

Nutrients·2026
Same author

Feasibility and early experience with venous Doppler congestion assessment in post-operative lung transplant patients.

The ultrasound journal·2026
Same authorSame journal

A mathematical framework for predicting tablet weight variability from blend particle size distribution and tooling geometry.

Journal of pharmaceutical sciences·2026
Same author

Derivation expansion of the general solubility equation (GSE).

Journal of pharmaceutical sciences·2026
Same author

Workforce, Deployment, and Characteristics of Clinical Pharmacy in Chilean Hospitals: A Nationwide Cross-Sectional Survey.

Journal of the American College of Clinical Pharmacy : JACCP·2026
Same author

Pediatric extended-release oral formulations: A U.S. market landscape analysis.

Journal of pharmaceutical sciences·2026
Same journal

Green, renewable, or low-carbon? A framework for informed solvent selection in pharmaceutical sciences.

Journal of pharmaceutical sciences·2026
Same journal

Theranostic potential of ramucirumab functionalized magnetoliposomes for targeted delivery of sorafenib and MRI.

Journal of pharmaceutical sciences·2026
Same journal

Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation.

Journal of pharmaceutical sciences·2026
Same journal

Evolving landscape of drug development for pediatric rare diseases-from successes to strategies for addressing unmet needs.

Journal of pharmaceutical sciences·2026
Same journal

Recrystallization can stop nitrosamine formation in ranitidine hydrochloride.

Journal of pharmaceutical sciences·2026
See all related articles

Johanson's rolling theory was tested for predicting roll compaction pressure. A modified model accurately predicts maximum roll surface pressure, improving pharmaceutical formulation analysis.

Area of Science:

  • Pharmaceutical Sciences
  • Chemical Engineering
  • Materials Science

Background:

  • Roll compaction is a key process in pharmaceutical manufacturing for producing solid dosage forms.
  • Accurate prediction of roll surface pressure is crucial for controlling ribbon density and tablet quality.
  • Johanson's rolling theory is a theoretical model used to estimate pressures in powder compaction.

Purpose of the Study:

  • To evaluate the predictive accuracy of Johanson's rolling theory for maximum roll surface pressure in pharmaceutical roll compaction.
  • To compare predictions from Johanson's model with experimental data from roller compaction and die compression.

Main Methods:

  • Three model pharmaceutical formulations were subjected to roller compaction using a Gerteis Mini Pactor.
Keywords:
die compressionformulationmaterial sciencemathematical modelmechanical propertiesmodified Johanson's rolling modelpowder technologyroller compaction

Related Experiment Videos

Last Updated: Apr 29, 2026

Fabrication of Carbon-Based Ionic Electromechanically Active Soft Actuators
14:42

Fabrication of Carbon-Based Ionic Electromechanically Active Soft Actuators

Published on: April 25, 2020

10.2K
  • Experiments were conducted across various combinations of roll forces and roll gaps.
  • Ribbon density was measured, and maximum roll surface pressure was predicted using Johanson's model and compared to die compression data.

    • Main Results:

    • Johanson's original model overpredicted the maximum roll surface pressure compared to die compression for achieving equivalent ribbon densities.
    • The root cause for the overprediction was identified and addressed.
    • A modified Johanson's rolling model demonstrated reasonably accurate predictions for the experimental conditions.

    Conclusions:

    • The original Johanson's rolling theory requires modification for accurate prediction of maximum roll surface pressure in pharmaceutical roller compaction.
    • The corrected model provides a valuable tool for optimizing roll compaction parameters and ensuring consistent product quality.
    • This study contributes to a better understanding of powder compaction mechanics in pharmaceutical manufacturing.