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Topical corticosteroids delay the proliferative response to sellotape stripping
F W Bauer1, J B Boezeman, J J Rijzewijk
1Hoffmann-La Roche AG, Basel, Switzerland.
Skin Pharmacology : the Official Journal of the Skin Pharmacology Society
|January 1, 1989
Summary
Corticosteroids like diprosone and hydrocortisone temporarily block skin cell recruitment after tape stripping. This finding aids in understanding antipsoriatic drug mechanisms and developing new treatments.
Area of Science:
- Dermatology
- Cell Biology
- Pharmacology
Background:
- Tape stripping normal human skin induces a hyperproliferative response.
- This response involves the recruitment of resting (G0) cells to proliferate.
Purpose of the Study:
- To investigate the effects of diprosone and hydrocortisone on the skin's hyperproliferative response to tape stripping.
- To understand the cellular mechanisms by which corticosteroids modulate this response.
Main Methods:
- Utilized flow cytometry to analyze cell cycle progression.
- Studied the impact of diprosone and hydrocortisone on tape-stripped human skin models.
Main Results:
- Both diprosone and hydrocortisone delayed the entry of recruited cells into the S-phase.
- Diprosone, a more potent antipsoriatic, exhibited a greater delay compared to hydrocortisone.
- Corticosteroids appear to induce a temporary G1 block or inhibit cell recruitment.
Conclusions:
- Corticosteroids temporarily inhibit the hyperproliferative response of human skin to tape stripping.
- The findings suggest a potential mechanism for antipsoriatic drug action.
- This model can be used for evaluating novel antipsoriatic agents.
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