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Related Experiment Videos

Histostitcher™: An informatics software platform for reconstructing whole-mount prostate histology using the

Robert J Toth1, Natalie Shih2, John E Tomaszewski3

  • 1Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, USA ; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.

Journal of Pathology Informatics
|May 21, 2014
PubMed
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Histostitcher™ software reconstructs whole mount histology sections from quadrants efficiently. This improved system enables better disease mapping by stitching histology images for pre-operative MRI correlation.

Area of Science:

  • Medical Imaging
  • Computational Pathology
  • Digital Histology

Background:

  • Co-registration of ex-vivo histology with pre-operative MRI aids disease extent mapping.
  • Ex-vivo histology images are often sectioned into quarters before imaging, posing reconstruction challenges.

Purpose of the Study:

  • To present Histostitcher™, a software system for creating pseudo whole mount histology sections (WMHS) from four individual histology quadrant images.
  • To improve upon an initial prototype with enhanced performance, memory efficiency, and workflow.

Main Methods:

  • Histostitcher™ utilizes user-identified fiducials for stitching histology quadrants.
  • The latest version is built on the extensible imaging platform (XIP™) architecture using C++.
  • Features include a GPU renderer for caching, improved workflow, and session management.
Keywords:
Computer aided diagnosisextensible imaging platformprostate histology

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Main Results:

  • The new Histostitcher™ platform demonstrates significantly improved workflow and reconstruction efficiency.
  • Performance remained consistent across various devices, including desktops, a Surface Pro tablet, and a multi-touch display.

Conclusions:

  • Histostitcher™ provides a fast and efficient framework for reconstructing pseudo WMHS from histology quadrants.
  • Future work will focus on mapping disease extent from pseudo WMHS onto pre-operative MRI scans.