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Related Concept Videos

Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Microorganisms in Medicine and Therapeutics01:29

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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In-vitro Mutagenesis01:16

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To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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Pharmacogenomics: Identification of New Drug Targets01:29

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Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
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Related Experiment Video

Updated: Apr 29, 2026

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells
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Gene therapy in India: a focus.

Sarvani Chodisetty1, Everette Jacob Remington Nelson

  • 1Gene Therapy Laboratory, School of Biosciences and Technology, VIT University, Vellore 632 014, India.

Journal of Biosciences
|May 22, 2014
PubMed
Summary

Gene therapy offers potential cures for genetic diseases. This review examines the current advancements and status of gene therapy applications in India, highlighting its emerging role in the Asian region.

Area of Science:

  • Biotechnology
  • Medical Genetics
  • Pharmacology

Background:

  • Gene therapy, a method for treating genetic disorders by replacing defective genes with functional copies, has evolved significantly since its inception.
  • Despite early setbacks in the late 1990s, gene therapy has resurged as a viable treatment option, supported by recent successful clinical trials.
  • The United States and Europe have led gene therapy research for over 20 years, with a growing interest now emerging from Asian countries.

Purpose of the Study:

  • To provide a comprehensive overview of the current state of gene therapy in India.
  • To analyze the progress and challenges of implementing gene therapy within the Indian healthcare landscape.
  • To contextualize India's gene therapy advancements within the broader global and Asian regional trends.

Main Methods:

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  • Literature review of published studies, clinical trial data, and regulatory information on gene therapy in India.
  • Analysis of research trends, therapeutic applications, and key players in the Indian gene therapy sector.
  • Comparative assessment of India's gene therapy landscape against international benchmarks.

Main Results:

  • Gene therapy research and application in India are gaining momentum, with increasing reports from clinical studies.
  • India is beginning to contribute to the global gene therapy field, following advancements in China, Japan, and Korea.
  • The review identifies key areas of focus and emerging opportunities for gene therapy in India.

Conclusions:

  • Gene therapy holds significant promise for treating genetic diseases in India.
  • Continued research, investment, and supportive regulatory frameworks are crucial for advancing gene therapy in India.
  • India is poised to become a notable contributor to the field of gene therapy in the coming years.