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Updated: Apr 29, 2026
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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
13.8K
B cells with immune-regulating function in transplantation
Jessica Stolp1, Laurence A Turka2, Kathryn J Wood1
1Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford John Radcliffe Hospital, Oxford OX3 9DU, UK.
Nature Reviews. Nephrology
|May 22, 2014
Summary
B cells play a complex role in organ transplantation, potentially causing rejection or promoting acceptance. This review explores regulatory B cells (Bregs) and their mechanisms in controlling immune responses to allografts.
Area of Science:
- Immunology
- Transplantation immunology
Background:
- B cells are implicated in allograft rejection via donor-specific antibodies.
- Emerging evidence suggests B cells can also regulate immune responses in transplantation.
- Understanding B cell roles in transplantation is limited and controversial.
Purpose of the Study:
- To review the phenotypes and functions of immune-regulating B cells in transplantation.
- To discuss the mechanisms by which regulatory B cells control immune responses to allografts.
Main Methods:
- Literature review of human and rodent studies on B cells in transplantation.
- Analysis of current understanding of regulatory B cell phenotypes and roles.
- Discussion of regulatory B cell mechanisms in transplant models.
Main Results:
- B cells have dual roles in transplantation: mediating rejection and regulating immune responses.
- Regulatory B cells (Bregs) exhibit diverse phenotypes and functions.
- Specific Breg subsets employ various mechanisms to modulate immune responses.
Conclusions:
- Regulatory B cells represent a promising therapeutic target in transplantation.
- Further research is needed to elucidate Breg heterogeneity and function in diverse clinical settings.
- Harnessing Breg activity could improve allograft outcomes.
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