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Updated: Apr 29, 2026
09:36
RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
Published on: April 10, 2018
27.7K
[The emerging landscape of long non-coding RNAs]
Yang Feng1, Yi Fan1, Cao Huiqing1
1Institute of Molecular Medicine, Peking University, Beijing 100871, China.
Yi Chuan = Hereditas
|May 22, 2014
Summary
Long non-coding RNAs (lncRNAs) were once considered junk DNA but are now known to regulate gene expression and are vital in biological processes and human diseases. This review covers lncRNA discovery, function, and disease roles.
Area of Science:
- Genomics
- Molecular Biology
- RNA Biology
Context:
- The Human Genome Project (HGP) initially identified protein-coding regions as a small fraction of the human genome.
- The ENCODE project revealed extensive transcription from previously disregarded genomic sequences.
- A significant portion of these transcripts are non-coding RNAs (ncRNAs), particularly long non-coding RNAs (lncRNAs).
Purpose:
- To review recent advancements in the study of long non-coding RNAs (lncRNAs).
- To discuss the discovery, classification, expression, and functional roles of lncRNAs.
- To explore the involvement of lncRNAs in the pathogenesis of human diseases.
Summary:
- Long non-coding RNAs (lncRNAs), transcripts longer than 200 nucleotides, play crucial roles in gene regulation at transcriptional and post-transcriptional levels.
- These molecules are essential for fundamental biological processes such as cell differentiation and organ development.
- Dysregulation of lncRNAs is increasingly linked to various human diseases, highlighting their clinical significance.
Impact:
- Advances understanding of the non-coding genome's functional importance.
- Provides insights into novel regulatory mechanisms in gene expression.
- Highlights potential therapeutic targets and biomarkers for human diseases.
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