Cigarette smoking and p300 amplitude in adults: a systematic review
Dawson Hedges1, David P Bennett2
1Department of Psychology, Brigham Young University, Provo, UT; Neuroscience Center, Brigham Young University, Provo, UT dawson_hedges@byu.edu.
Objective:
To determine the association between chronic tobacco cigarette smoking and P300 amplitude.
Design:
Systematic review with meta-analysis and meta-regression.
Data Sources:
Medline, Cochrane Database of Systematic Reviews, PsychInfo, and Web of Science.
Eligibility Criteria For Selecting Studies:
Eligible studies contained P300 amplitudes obtained from either visual or auditory stimuli and standard deviations or errors in female and male subjects older than 18 years in a group of nonabstaining chronic cigarette smokers and a nonsmoking control group.
Results:
The 9 eligible studies comprised 13 relevant datasets containing 1,956 current cigarette smokers and 2,194 nonsmoking controls (N = 4,150). The P300 amplitude was smaller in cigarette smokers than in nonsmoking controls (Hedges' g effect size = .365; 95% confidence interval [CI] = 0.196-0.534, p < .001). Meta-regression showed significant positive associations between the number of cigarettes smoked per day at the time of the study (slope estimate = .036, 95% CI = 0.016-0.056, p ≤ .001, length of smoking in years (slope estimate = .056, 95% CI = 0.005-0.102, p = .018), pack years (slope estimate = .018, 95% CI = 0.009-0.031 p = .009), and age (slope estimate = .068, 95% CI = 0.025-0.113, p = .002).
Conclusions:
P300 amplitude was smaller in cigarette smokers than in nonsmoking controls, and a possible dose-response relationship was apparent. Findings indicate a possible association between cigarette smoking and decreased P300 amplitude.
