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Related Experiment Video

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Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
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Proactive and reactive inhibitory control in rats.

Jeffrey D Mayse1, Geoffrey M Nelson2, Pul Park3

  • 1Department of Psychological and Brain Sciences, Johns Hopkins University Baltimore, MD, USA ; Neural Circuits and Cognition Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health Baltimore, MD, USA.

Frontiers in Neuroscience
|May 22, 2014
PubMed
Summary

Researchers developed a rodent stop signal task (SST) to study inhibitory control. They identified distinct error types in rats and created a new method to accurately measure stop signal reaction time (SSRT).

Keywords:
decision makingexecutive functionimpulsivityinhibitory controlproactivereactivestop signalstop signal reaction time

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Area of Science:

  • Neuroscience
  • Behavioral Science

Background:

  • Inhibitory control, essential for survival, involves reactive and proactive strategies.
  • The stop signal task (SST) is a key paradigm for studying inhibitory control.
  • Translating the SST to rodents is crucial for understanding neural mechanisms but faces design challenges.

Purpose of the Study:

  • To develop a rodent-appropriate SST to study inhibitory control in rats.
  • To characterize reactive and proactive inhibitory control strategies in rodents.
  • To address discrepancies between rodent and primate SST studies.

Main Methods:

  • Developed a novel rodent-appropriate stop signal task (SST).
  • Analyzed reactive inhibitory control errors, distinguishing failure-to-stop from failure-to-wait.
  • Developed and validated a new method for unbiased stop signal reaction time (SSRT) estimation.

Main Results:

  • Rodent errors in the SST comprise independent failure-to-stop and failure-to-wait types.
  • Conflating these errors leads to overestimation of the stop signal reaction time (SSRT).
  • Rodents exhibit proactive control adjustments following specific error types and successful stops.

Conclusions:

  • Established a valid rodent model for studying inhibitory control, mirroring primate strategies.
  • Highlighted the necessity of dissociating initial stopping from subsequent waiting for accurate SSRT measurement.
  • Emphasized the importance of task design for comparative studies of inhibitory control mechanisms.