Related Experiment Video
Updated: Apr 29, 2026
08:50
Deep Neuromuscular Blockade Leads to a Larger Intraabdominal Volume During Laparoscopy
Published on: June 25, 2013
12.6K
Hypersensitivity associated with sugammadex administration: a systematic review
1Soroka University Medical Center, Ben-Gurion University of the Negev, Be'er Sheva, Israel.
Anaesthesia
|May 23, 2014
Summary
Sugammadex can cause hypersensitivity reactions, including anaphylaxis, within minutes of administration. Healthcare providers should monitor patients closely for these critical events post-administration.
Area of Science:
- Anesthesiology
- Pharmacology
- Immunology
Background:
- Sugammadex reverses neuromuscular blockade but faces FDA approval delays due to hypersensitivity concerns.
- Hypersensitivity reactions to sugammadex require further characterization.
Purpose of the Study:
- To identify common features of hypersensitivity reactions to sugammadex.
- To raise awareness of sugammadex-induced hypersensitivity.
Main Methods:
- Systematic literature review of PubMed, Scopus, and Web of Science.
- Inclusion of case reports with detailed hypersensitivity descriptions and exclusion of alternative causes.
- Contacted regulatory agencies and the manufacturer for unpublished reports.
Main Results:
- Fifteen cases of hypersensitivity to sugammadex were identified.
- The majority of reactions (14/15) occurred within 4 minutes of administration.
- 73% (11/15) of patients met criteria for anaphylaxis.
Conclusions:
- Sugammadex-induced hypersensitivity, particularly anaphylaxis, often presents rapidly within minutes.
- Increased vigilance is necessary during the immediate post-administration period for sugammadex.
Related Concept Videos
01:30Drug Toxicity: Allergic Reactions
207
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
207
01:12Local Anesthetics: Adverse Effects
1.0K
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
1.0K
01:29Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
359
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
359
01:19Hypersensitivity Reactions: Immune-Complex Reactions
269
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
269
01:21Skeletal Muscle Relaxants: Adverse Effects
1.2K
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Unlike...
1.2K
01:30Hypersensitivities
7.3K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.3K