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Updated: Apr 29, 2026

Flow Cytometric Characterization of Murine B Cell Development
Published on: January 22, 2021
Reprint of: Environments of B cell development
Motokazu Tsuneto1, Ekaterina Kajikhina1, Katharina Seiler1
1Max Planck Institute for Infection Biology, Lymphocyte Development Group, Berlin, Germany.
Abstract:
B lymphocyte development in the mouse begins with the generation of long-term reconstituting, pluripotent hematopoietic stem cells, over multipotent myeloid/lymphoid progenitors and common lymphoid progenitors to B-lineage committed pro/pre B and pre B cells, which first express pre B cell receptors and then immunoglobulins, B cell receptors, to generate the repertoires of peripheral B cells. This development is influenced and guided by cells of non-hematopoietic and hematopoietic origins. We review here some of the recent developments, and our contributions in this fascinating field of developmental immunology.
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