Related Experiment Video
Updated: Apr 29, 2026
Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
Published on: October 15, 2019
Upon the photostability of 8-nitro-cGMP and its caging as a 7-dimethylaminocoumarinyl ester
Ayan Samanta1, Martin Thunemann, Robert Feil
1Interfaculty Institute of Biochemistry, University of Tübingen, Auf der Morgenstelle 15, D-72076 Tübingen, Germany. thorsten.stafforst@uni-tuebingen.de.
Abstract:
8-Nitro-cGMP was recently discovered as a second messenger of nitric oxide. We describe here the synthesis and properties of DMACM-modified 8-nitro-cGMP for photochemical uncaging. Owing to the limited photostability of 8-nitro-cGMP care must be taken, but the photorelease of the intact product was readily feasible. Unexpectedly, 8-nitro-cGMP decays under formation of 8-nitrosoguanine when irradiated with light.
More Related Videos
07:15Measurement of Cyclic Guanosine Monophosphate (cGMP) in Solid Tissues using Competitive Enzyme-Linked Immunosorbent Assay (ELISA)
Published on: July 3, 2025
07:03Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
Published on: January 31, 2014