Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Postnatal development of renal function.

P A Jose1, R D Fildes

  • 1Department of Pediatrics, Georgetown University Medical Center, Washington, DC, USA.

Mead Johnson Symposium on Perinatal and Developmental Medicine
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Drug Repurposing: An Effective Tool in Modern Drug Discovery.

Russian journal of bioorganic chemistry·2023
Same author

In vivo predation and modification of the Mediterranean fruit fly Ceratitis capitata (Wiedemann) gut microbiome by the bacterial predator Bdellovibrio bacteriovorus.

Journal of applied microbiology·2021
Same author

Dopaminergic Immunofluorescence Studies in Kidney Tissue.

Methods in molecular biology (Clifton, N.J.)·2017
Same author

Secreted Monocyte miR-27a Causes Hypertension by Reducing Mas Receptor Expression and Function in the Artery.

Journal of the American Society of Hypertension : JASH·2016
Same author

Role of GRK4 in the Regulation of Arterial AT1 Receptor in Hypertension.

Journal of the American Society of Hypertension : JASH·2016
Same author

Irisin Lowered Blood Pressure by Augmenting Acetylcholine-Mediated Vasodilation via AMPK-Akt-eNOS-NO Signal Pathway in the Spontaneously Hypertensive Rat.

Journal of the American Society of Hypertension : JASH·2016
Same journal

The sources and actions of the human colony stimulating factors.

Mead Johnson Symposium on Perinatal and Developmental Medicine·1988
Same journal

Acute renal failure in the newborn.

Mead Johnson Symposium on Perinatal and Developmental Medicine·1988
Same journal

Retinopathy of prematurity.

Mead Johnson Symposium on Perinatal and Developmental Medicine·1988
Same journal

High frequency ventilation.

Mead Johnson Symposium on Perinatal and Developmental Medicine·1988
Same journal

Changing outcome of the tiny infant.

Mead Johnson Symposium on Perinatal and Developmental Medicine·1988
Same journal

Bronchopulmonary dysplasia.

Mead Johnson Symposium on Perinatal and Developmental Medicine·1988
See all related articles

Neonatal kidney function differs significantly from adults, representing adaptations for growth rather than just immaturity. These unique renal characteristics can offer protection against certain drug toxicities in newborns.

Area of Science:

  • Neonatal physiology
  • Pediatric nephrology
  • Developmental biology

Background:

  • Neonatal renal function exhibits distinct qualitative and quantitative differences compared to older individuals.
  • Gestational age significantly influences the interpretation of renal functional variations in newborns.
  • These functional differences are often adaptive, supporting growth and development, rather than solely indicative of immaturity.

Purpose of the Study:

  • To elucidate the unique aspects of renal function in newborns.
  • To understand the implications of neonatal renal function for health and development.
  • To explore the potential benefits of altered renal function in neonates, particularly concerning medication efficacy and safety.

Main Methods:

  • Comparative analysis of renal function parameters between neonates and adults.

Related Experiment Videos

  • Assessment of the impact of gestational age on renal functional characteristics.
  • Evaluation of the functional reserve and transport properties of the neonatal kidney.

    • Main Results:

    • Neonatal renal function is quantitatively and qualitatively different, influenced by gestational age.
    • Decreased functional reserve makes the neonatal kidney vulnerable to stress.
    • Lower glomerular filtration rate (GFR) and altered transport properties may benefit neonates.
    • Certain drugs exhibit reduced nephrotoxicity in newborns compared to adults due to these functional differences.

    Conclusions:

    • Neonatal renal function represents age-appropriate adaptations crucial for growth.
    • Despite lower functional reserve, specific renal characteristics offer advantages, including potential protection against nephrotoxicity.
    • Understanding these differences is vital for appropriate clinical management and therapeutic interventions in neonates.