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Prevention and management of co-morbidities in SLE

Tanmayee Bichile1, Michelle Petri1

  • 1Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, Maryland 21205, United States.

Presse Medicale (Paris, France : 1983)
|May 24, 2014
PubMed

Insights

Systemic lupus erythematosus (SLE) survival has improved, with cardiovascular disease now a leading cause of death. Reducing corticosteroid use, particularly prednisone, is crucial for managing cardiovascular risk in SLE patients.

Area of Science:

  • Rheumatology
  • Cardiology
  • Nephrology

Background:

  • Systemic lupus erythematosus (SLE) prognosis has significantly improved.
  • Cardiovascular disease, renal failure complications, and malignancy are now leading causes of mortality in SLE patients, surpassing active lupus disease.
  • Both traditional and non-traditional cardiovascular risk factors are significant in SLE management.

Purpose of the Study:

  • To highlight the shift in mortality causes for SLE patients.
  • To emphasize the role of cardiovascular risk factors in SLE.
  • To underscore the detrimental cardiovascular effects of corticosteroids and advocate for lower prednisone doses.

Main Methods:

  • Review of current literature on SLE prognosis and mortality.
  • Analysis of cardiovascular risk factors in SLE patients.
  • Evaluation of the impact of corticosteroid therapy on cardiovascular health.

Main Results:

  • Improved survival rates in SLE patients.
  • Identification of cardiovascular disease as a primary cause of death.
  • Recognition of corticosteroids, specifically prednisone, as a contributor to cardiovascular risk.

Conclusions:

  • Management strategies for SLE must prioritize cardiovascular health.
  • Minimizing corticosteroid exposure, especially long-term prednisone use, is essential for reducing cardiovascular morbidity and mortality in SLE.
  • Targeting modifiable cardiovascular risk factors is key to improving long-term outcomes for SLE patients.

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