Bilateral diffuse uveal melanocytic proliferation: a management dilemma

Area of Science:

• Ophthalmology
• Oncology

Background:

• Bilateral diffuse uveal melanocytic proliferation (BDUMP) syndrome is a rare condition.
• It is often associated with paraneoplastic phenomena, but can occur without evidence of malignancy.

Observation:

• A female patient experienced gradual vision decline.
• She presented with bilateral choroidal tumors and overlying retinal changes, suggestive of BDUMP syndrome.
• No concurrent malignancy was identified during initial or subsequent surveillance over 4 years.

Findings:

• The patient exhibited relentless, progressive vision deterioration due to BDUMP syndrome.
• Despite the absence of an identified cancer, the condition significantly impacted visual function.

Implications:

• This case highlights the challenges in managing vision loss associated with BDUMP syndrome.
• The paraneoplastic nature of BDUMP syndrome, even without detected cancer, necessitates ongoing monitoring and research into effective treatments.