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Updated: Apr 29, 2026

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
Published on: July 28, 2022
Ring-closing metathesis reactions of bis(enynes): selectivity and surprises
Debra J Wallace1, Robert A Reamer
1Department of Process Chemistry, Merck Research Laboratories , PO Box 2000, Rahway, New Jersey 07065, United States.
Abstract:
A study of the ring-closing metathesis reactions of two bis(enynes) is presented. These substrates, which contain two alkenes and two alkynes, as well as a resident stereocenter, can potentially generate metathesis products resulting from many reaction pathways. In this contribution we present our results on these reactions, show how small changes in reaction conditions can lead to different product ratios, and attempt to provide a rationale for the outcomes.
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