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Published on: July 29, 2014
Sex and gender influences on pharmacological response: an overview
Flavia Franconi1, Ilaria Campesi
1Departiment of Biomedical Sciences, University of Sassari, Via Muroni 23, 07100 Sassari, Italy.
Abstract:
Research on the specific effects of sex and gender on pharmacokinetics and pharmacodynamics, as well as safety profile tolerability and drug efficacy, of medications remain meager because female animals and women have only recently been included in the pharmacological domain. To date, the influence of sex and gender on access to care and emotional factors, including patients and care provider dyads, the placebo effect, adherence, and safety profiles, are discussed. Furthermore, differences in drug responses, mainly for antidiabetic drugs, have been described. However, further studies are needed to explore the impact of sex and gender on reaching the most appropriate and tailored prescription for each patient, regardless of sex and gender.
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