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Related Experiment Video

Updated: May 28, 2026

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

Sex-Related Differences in Circular RNA Expression in Multiple Sclerosis: A Pilot Study.

Valeria Lodde1, Ignazio Roberto Zarbo2,3, Gabriele Farina3

  • 1Department of Biomedical Sciences, University of Sassari, Sassari, 07100, Italy. vlodde@uniss.it.

Journal of Molecular Neuroscience : MN
|May 26, 2026
PubMed
Summary
This summary is machine-generated.

This study found sex-based differences in circular RNA (circRNA) expression in multiple sclerosis (MS) patients. Specific circRNAs like hsa_circ_0140253 were linked to MS severity and treatment, highlighting the need for sex-specific research.

Keywords:
Circular RNAsGene regulationImmune regulationMultiple sclerosisSex differences

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Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

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Last Updated: May 28, 2026

Identification of Circular RNAs using RNA Sequencing
08:25

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Published on: November 14, 2019

Use of Alu Element Containing Minigenes to Analyze Circular RNAs
13:10

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Published on: March 10, 2020

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
05:44

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

Published on: October 13, 2023

Area of Science:

  • Neuroimmunology
  • Molecular Biology
  • Genomics

Background:

  • Multiple Sclerosis (MS) is an autoimmune CNS disease with a higher prevalence in females.
  • Sex differences impact MS susceptibility and progression.
  • Circular RNAs (circRNAs) are key regulators of CNS and immune functions, but their role in MS is unclear.

Purpose of the Study:

  • To investigate sex-specific differences in circRNA expression in MS patients.
  • To identify circRNAs associated with MS severity and disease-modifying therapies (DMTs).

Main Methods:

  • Re-analysis of a published dataset with sex-stratified analysis.
  • Validation of differentially expressed circRNAs in an independent cohort of MS patients.
  • Correlation analysis between circRNA expression and clinical variables (disability, disease form, DMTs).

Main Results:

  • Identified 33 differentially expressed circRNAs between female and male MS patients.
  • Validated sex-dependent expression differences for five circRNAs.
  • Found hsa_circ_0140253 expression correlated with higher disability and progressive MS, and with DMT use.

Conclusions:

  • circRNA expression in MS is influenced by sex, disease severity, and DMT exposure.
  • Preliminary evidence suggests circRNAs may play a role in MS pathogenesis.
  • Further research in larger cohorts is needed to confirm these sex-related findings and their clinical implications.