Multifunctional tunable p(inulin) microgels
Nurettin Sahiner1, Selin Sagbas2
1Faculty of Science & Arts, Chemistry Department, Canakkale Onsekiz Mart University, Terzioglu Campus, 17100 Canakkale, Turkey; Nanoscience and Technology Research and Application Center (NANORAC), Canakkale Onsekiz Mart University, Terzioglu Campus, 17100 Canakkale, Turkey.
Summary
Novel inulin microgels, including porous and charged variants, were developed for drug delivery. Their absorption and release rates for rosmarinic acid were found to be significantly influenced by microgel porosity and zeta potential.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Inulin is a biopolymer with potential applications in drug delivery.
- Developing advanced inulin-based carriers is crucial for improving therapeutic efficacy.
- Microemulsion techniques offer a versatile platform for creating complex microgel structures.
Purpose of the Study:
- To synthesize inulin, inulin-silica, and modified inulin microgels.
- To create porous inulin microgels by silica template removal.
- To quaternize inulin microgels for cationic modification and evaluate their drug delivery performance.
Main Methods:
- Microemulsion crosslinking technique for inulin microgel synthesis.
- Inulin-silica composite particle formation using tetraethyl orthosilicate (TEOS).
- Silica template dissolution to create porous inulin particles.
- Quaternization of inulin microgels using 3-chloro-2-hydroxypropyl trimethyl ammonium chloride (CHPTMAC).
- Drug loading and release studies using rosmarinic acid (RA) in phosphate buffer solution (PBS) at pH 7.4.
Main Results:
- Successfully synthesized inulin, inulin-silica, and modified inulin microgels.
- Generated porous inulin microgels via silica template dissolution.
- Achieved quaternization of inulin microgels, resulting in positively charged particles (q-p(inulin)).
- Demonstrated that rosmarinic acid absorption and release kinetics are dependent on microgel porosity and zeta potential.
Conclusions:
- Inulin-based microgels can be effectively prepared using microemulsion techniques.
- Porosity and surface charge (zeta potential) are critical parameters controlling drug absorption and release from these inulin microgels.
- These findings highlight the potential of tailored inulin microgels as versatile drug delivery platforms.
