Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Redox Reactions

Redox Reactions

Redox reactions are vital biochemical processes that underpin energy metabolism in cells. These reactions involve the transfer of electrons between molecules, occurring in tandem as oxidation and reduction. Oxidation refers to the loss of electrons, while reduction denotes their gain. This coupling ensures the seamless flow of electrons through metabolic pathways. For example, in bacterial metabolism, glucose undergoes oxidation to carbon dioxide, while oxygen is simultaneously reduced to...

Redox Reactions

Redox Reactions

Oxidation-reduction or redox reactions involve the transfer of electrons from one molecule or atom to another. When an atom gains an electron, another atom must lose an electron, meaning oxidation and reduction must occur together. Since the redox occurs in pairs, the atom that gets oxidized is also called the reducing agent or reductant, and the atom that is reduced is also called the oxidizing agent or oxidant. A straightforward way to remember the definitions of oxidation and reduction is...

Balancing Redox Equations

Balancing Redox Equations

Electrochemistry is the science involved in the interconversion of electrical and chemical reactions. Such reactions are called reduction-oxidation, or redox reactions. These important reactions are defined by changes in oxidation states for one or more reactant elements and include a subset of reactions involving the transfer of electrons between reactant species. Electrochemistry as a field has evolved to yield sufficient insights on the fundamental principles of redox chemistry and multiple...

Oxidation-Reduction Reactions

Oxidation-Reduction Reactions

Oxidation–Reduction Reactions

Synthesis and Decomposition Reactions

Synthesis and Decomposition Reactions

Synthesis and decomposition are two types of redox reactions. Synthesis means to make something, whereas decomposition means to break something. The reactions are accompanied by chemical and energy changes.

Redox Equilibria: Overview

Redox Equilibria: Overview

A reduction-oxidation reaction is commonly called a redox reaction. In a redox reaction, electrons are transferred from one species to another rather than being shared between or among atoms. The reducing agent or reductant is the species that loses electrons and gets oxidized in the process. The species that gains electrons and gets reduced in the process is the oxidizing agent or oxidant. Redox reactions are represented as two separate equations called half-reactions, where one equation...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Acridine/Lewis acid photocatalysis enables α-amidyl radical cyclizations.

Organic chemistry frontiers : an international journal of organic chemistry·2026

Same author

Photoredox-Neutral Platform for Direct Decarboxylative Cyclopropanation <i>via</i> Acridine-Iron Dual Catalysis.

ACS catalysis·2026

Same author

Cyclic Imine-BF<sub>3</sub> Complexes as Precursors for Functionalized Azacycles.

Synlett : accounts and rapid communications in synthetic organic chemistry·2026

Same author

Photocatalytic α-alkylation of carbamates with vinyl azaarenes.

ARKIVOC : free online journal of organic chemistry·2026

Same author

Catalytic Enantioselective Synthesis of 1,1-Disubstituted Isochromans.

Journal of the American Chemical Society·2026

Same author

Nitroarene Photoactivation Promotes Oxidative Deconstruction of Olefinic Polymers.

ACS macro letters·2025

Same journal

Generation of Carbon and Phosphine Stereocenters via Cobaltaphotoredox-Catalyzed Enantioselective C-H Annulation.

Organic letters·2026

Same journal

Construction of β-Hydroxysulfones via a Photoinduced Four-Component Reaction.

Organic letters·2026

Same journal

The Development of a Highly Stereoselective Zn-Catalyzed (3 + 2) Cycloaddition of Azomethine Ylides and Nitroalkenes.

Organic letters·2026

Same journal

Visible-Light-Induced Nickel-Catalyzed Enantioconvergent C(sp<sup>3</sup>)-C(sp<sup>3</sup>) Coupling of α-Bromoamides with Alkene-Derived Alkylzirconocenes.

Organic letters·2026

Same journal

Pd-Catalyzed Regioselective Activation of <i>gem</i>-Difluorinated Spiro[2.2]pentanes: An Approach to 2-Fluorinated 1,3-Dienes.

Organic letters·2026

Same journal

General Cascade Esterification-Pentafluorosulfanyloxylation of Carboxylic Acids with Cyclic Ethers using Silver Pentafluorooxosulfate.

Organic letters·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 12, 2026

Cellular Redox Profiling Using High-content Microscopy

Cellular Redox Profiling Using High-content Microscopy

Published on: May 14, 2017

The redox-Mannich reaction.

Weijie Chen¹, Daniel Seidel

¹Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey , Piscataway, New Jersey 08854, United States.

Organic Letters

|May 27, 2014

Summary

This summary is machine-generated.

The redox-Mannich reaction offers a new route to ring-substituted β-amino ketones. This method uses mild conditions and benzoic acid, complementing the traditional Mannich reaction.

More Related Videos

EPR Monitored Redox Titration of the Cofactors of Saccharomyces cerevisiae Nar1

EPR Monitored Redox Titration of the Cofactors of Saccharomyces cerevisiae Nar1

Published on: November 26, 2014

Profiling Thiol Redox Proteome Using Isotope Tagging Mass Spectrometry

Profiling Thiol Redox Proteome Using Isotope Tagging Mass Spectrometry

Published on: March 24, 2012

Related Experiment Videos

Last Updated: Feb 12, 2026

Cellular Redox Profiling Using High-content Microscopy

Cellular Redox Profiling Using High-content Microscopy

Published on: May 14, 2017

EPR Monitored Redox Titration of the Cofactors of Saccharomyces cerevisiae Nar1

EPR Monitored Redox Titration of the Cofactors of Saccharomyces cerevisiae Nar1

Published on: November 26, 2014

Profiling Thiol Redox Proteome Using Isotope Tagging Mass Spectrometry

Profiling Thiol Redox Proteome Using Isotope Tagging Mass Spectrometry

Published on: March 24, 2012

Area of Science:

Organic Chemistry
Synthetic Chemistry

Background:

The Mannich reaction is a fundamental carbon-carbon bond-forming reaction in organic synthesis.
Traditional Mannich reactions produce β-amino carbonyl compounds.
Limitations exist in controlling regioselectivity for ring-substituted products.

Purpose of the Study:

To introduce the novel redox-Mannich reaction as an advancement over the classic Mannich reaction.
To demonstrate a facile method for preparing ring-substituted β-amino ketones.
To explore reaction conditions that facilitate the synthesis.

Main Methods:

Utilizing the same starting materials as the classic Mannich reaction.
Incorporating a key isomerization step.
Employing benzoic acid as a catalyst or facilitator.
Conducting reactions under relatively mild conditions.

Main Results:

Successful and facile preparation of ring-substituted β-amino ketones.
Demonstration of the redox-Mannich reaction as a viable synthetic pathway.
Identification of mild reaction conditions beneficial for synthesis.

Conclusions:

The redox-Mannich reaction provides a valuable complementary approach to the classic Mannich reaction.
This method allows for the efficient synthesis of specifically substituted β-amino ketones.
The reaction's mild conditions and use of benzoic acid make it an attractive synthetic tool.