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Pterygium is related to a decrease in corneal endothelial cell density.

Min-Yen Hsu1, Hsin-Nung Lee, Chiao-Ying Liang

  • 1*Department of Ophthalmology, Taichung Veterans General Hospital, Taichung, Taiwan; and †The Institute of Nanoengineering and Microsystems, National Tsing Hua University, Hsinchu, Taiwan.

Cornea
|May 27, 2014
PubMed
Summary
This summary is machine-generated.

Pterygium significantly reduces corneal endothelial cell density (ECD), especially with larger pterygium size and increased astigmatism. Early surgical intervention is recommended for extensive pterygium.

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Area of Science:

  • Ophthalmology
  • Corneal Diseases
  • Cell Biology

Background:

  • Pterygium, a common ocular condition, can affect corneal health.
  • Corneal endothelial cell density (ECD) is crucial for maintaining corneal transparency and function.

Purpose of the Study:

  • To investigate the relationship between pterygium and corneal endothelial cell density (ECD) in patients with unilateral primary pterygium.
  • To assess the impact of pterygium size and astigmatism on ECD.

Main Methods:

  • Retrospective cross-sectional study of 90 patients with unilateral primary pterygium.
  • Corneal ECD measured in both affected and fellow (control) eyes.
  • Pearson correlation used to analyze the association between pterygium size, astigmatism, and ECD decrease.

Main Results:

  • A strong logarithmic correlation was found between decreased ECD and pterygium size (R = 0.688, P < 0.001).
  • Eyes with pterygium showed a median ECD decrease of 9.75% compared to control eyes.
  • Increased astigmatism in pterygium-affected eyes was also associated with reduced ECD.

Conclusions:

  • Pterygium is significantly associated with a reduction in corneal endothelial cell density.
  • Extensive pterygium or significant astigmatism increase warrants consideration for surgical intervention to preserve corneal health.