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Challenges and future prospects of antibiotic therapy: from peptides to phages utilization

Santi M Mandal1, Anupam Roy1, Ananta K Ghosh1

  • 1Central Research Facility, Department of Chemistry and Department of Biotechnology, Indian Institute of Technology Kharagpur Kharagpur, India.

Frontiers in Pharmacology
|May 27, 2014
PubMed

Insights

The rise of multi-drug-resistant (MDR) bacterial infections necessitates novel antibiotics. This review explores promising new antimicrobial compounds and therapies to combat these growing global health threats.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Drug Discovery

Background:

  • Global rise of multi-drug-resistant (MDR) bacterial pathogens poses a significant threat to public health.
  • Decreasing effectiveness of conventional antibiotics is primarily driven by misuse in human and veterinary medicine.
  • Urgent need for novel antimicrobial agents with distinct mechanisms of action against MDR bacteria.

Purpose of the Study:

  • To review current and emerging strategies for discovering next-generation antibiotics.
  • To highlight diverse therapeutic avenues for combating MDR bacterial infections.
  • To provide insights into future research directions for novel antimicrobial compounds.

Main Methods:

  • Comprehensive literature review of recent research on novel antimicrobial strategies.
  • Analysis of various classes of potential antibiotics, including peptides, phages, and small molecules.
  • Examination of therapeutic approaches targeting bacterial resistance mechanisms.

Main Results:

  • Identified several promising avenues for new antibiotic development.
  • Antimicrobial peptides, phage therapy, phytochemicals, metalloantibiotics, and efflux pump inhibitors show potential.
  • Lipopolysaccharide-based strategies also present a novel approach.

Conclusions:

  • A multi-pronged approach combining various novel strategies is crucial for addressing the MDR crisis.
  • Continued research and development are essential to discover and implement effective treatments.
  • Future antibiotics must be safe, effective, and target diverse mechanisms to overcome resistance.
Keywords:
antibioticsinfection controlmulti-drug-resistant pathogens

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