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Updated: Apr 29, 2026

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
Published on: June 15, 2020
Is autonomic function associated with left ventricular systolic function in Chagas heart disease patients undergoing
Lotte Raadschilders1, Manoel Otavio da Costa Rocha1, Lidiane Sousa1
1Faculdade de Medicina e Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BRAZIL.
Introduction:
The association between cardiac autonomic and left ventricular (LV) dysfunction in Chagas disease (ChD) is controversial.
Methods:
A standardized protocol that includes the Valsalva maneuver, a respiratory sinus arrhythmia (RSA) test, and an echocardiographic examination was used. Spearman correlation coefficients (rho) were used to investigate associations.
Results:
The study population consisted of 118 ChD patients undergoing current medical treatment, with an average LV ejection fraction of 51.4±2.6%. The LV ejection fraction and diastolic dimension were correlated with the Valsalva index (rho=0.358, p<0.001 and rho=-0.266, p=0.004, respectively) and the RSA (rho=0.391, p<0.001 and rho=-0.311, p<0.001, respectively).
Conclusions:
The impairment of LV function is directly associated with a reduction of cardiac autonomic modulation in ChD.
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