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Related Concept Videos

Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
Yellow Fever01:18

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...

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Related Experiment Video

Updated: Jul 12, 2026

Protocol for Dengue Infections in Mosquitoes (A. aegypti) and Infection Phenotype Determination
15:25

Protocol for Dengue Infections in Mosquitoes (A. aegypti) and Infection Phenotype Determination

Published on: July 4, 2007

Age and Gender-Based Clinical and Laboratory Features in Dengue Infection: A Comparative Study.

Sulistiawati1, Linda Dewanti1, Alpha Fardah Athiyyah2

  • 1Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.

Journal of Infection in Developing Countries
|July 10, 2026
PubMed
Summary

Dengue diagnosis shows significant clinical and laboratory differences between children and adults. Age-specific diagnostics are crucial for early detection and effective dengue treatment.

Keywords:
adultschildrendenguehealthhumanmedicine

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Last Updated: Jul 12, 2026

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Portable Paper-Based Immunoassay Combined with Smartphone Application for Colorimetric and Quantitative Detection of Dengue NS1 Antigen

Published on: January 26, 2024

Area of Science:

  • Infectious Diseases
  • Clinical Medicine
  • Epidemiology

Background:

  • Dengue infection is a global health concern with increasing adult cases.
  • Accurate diagnosis by the World Health Organization (WHO) relies on clinical and laboratory markers.
  • Understanding age-related variations in dengue presentation is essential for effective management.

Purpose of the Study:

  • To investigate age and gender-based differences in clinical and laboratory findings of dengue infection.
  • To compare dengue fever (DF) and dengue hemorrhagic fever (DHF) presentation across pediatric and adult populations.
  • To identify specific laboratory parameters that vary with age in dengue patients.

Main Methods:

  • An analytical cross-sectional study was conducted using medical records of 162 dengue patients.
  • Data from pediatric and adult patients hospitalized in 2022 were analyzed.
  • Laboratory parameters including hemoglobin, hematocrit, leukocyte, and platelet counts were assessed across six age groups.

Main Results:

  • No significant difference in DF/DHF classification between pediatric and adult patients (p=0.085).
  • A significant difference in thrombocytopenia incidence was observed between children and adults (p=0.019).
  • Lower platelet counts were significantly associated with dengue hemorrhagic fever (DHF) compared to dengue fever (DF) (p=0.001).

Conclusions:

  • Significant clinical and laboratory differences exist between pediatric and adult dengue patients.
  • Age-specific diagnostic approaches are necessary for improved early detection.
  • Tailoring dengue treatment based on age-related findings can enhance patient outcomes.