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Ketamine for intravenous regional anesthesia.
Z Durrani1, A P Winnie, E K Zsigmond
1Department of Anesthesiology, University of Illinois College of Medicine, Chicago.
Anesthesia and Analgesia
|March 1, 1989
Summary
Ketamine intravenous regional anesthesia (IVRA) at 0.5% and 0.3% concentrations provided adequate upper extremity anesthesia in volunteers. However, psychotomimetic side effects limit ketamine
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Intravenous regional anesthesia (IVRA) is a technique for limb anesthesia.
- Ketamine, an anesthetic agent, has been explored for IVRA.
Purpose of the Study:
- To evaluate the efficacy and side effects of ketamine for IVRA of the upper extremity.
Main Methods:
- Volunteers received ketamine IVRA at 0.5%, 0.3%, and 0.2% concentrations.
- Anesthesia, sympathetic, sensory, and motor blockade were assessed.
Main Results:
- 0.5% and 0.3% ketamine concentrations produced adequate anesthesia.
- 0.2% concentration resulted in inadequate anesthesia.
- 0.3% concentration caused significant psychotomimetic effects post-tourniquet release.
Conclusions:
- Ketamine at 0.5% and 0.3% is effective for upper extremity IVRA.
- Unpleasant psychotomimetic effects limit ketamine's utility in IVRA.
- Further research is needed to mitigate ketamine's side effects for IVRA.