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Published on: January 7, 2019
PML control of cytokine signaling
Ghizlane Maarifi1, Mounira K Chelbi-Alix1, Sébastien Nisole1
1INSERM UMR-S 1124, Université Paris Descartes, 45 rue des Saint-Pères, 75006 Paris, France.
Abstract:
The promyelocytic leukemia (PML) protein is a tumor suppressor acting as the organizer of nuclear matrix-associated structures named nuclear bodies (NBs). The involvement of PML in various cell processes, including cell death, senescence or antiviral defense underlines the multiple functions of PML due to its ability to interact with various partners either in the cytoplasm or in the nucleus. The importance of paracrine signaling in the regulation of PML expression is well established. More recently, a growing body of evidence also supports PML as a key regulator of cytokine signaling. These findings shed light on unsuspected biological functions of PML such as immune response, inflammation and cytokine-induced apoptosis. Here we review the current understanding of the pleiotropic activities of PML on cytokine-induced signaling.
Insights
The promyelocytic leukemia (PML) protein organizes nuclear bodies and regulates cell processes. PML is a key regulator of cytokine signaling, impacting immune response and inflammation.
Area of Science:
- Cell Biology
- Molecular Biology
- Immunology
Background:
- The promyelocytic leukemia (PML) protein is a crucial tumor suppressor.
- PML protein organizes nuclear bodies (NBs), influencing cell death, senescence, and antiviral defense.
- Paracrine signaling regulates PML expression, with emerging evidence linking PML to cytokine signaling.
Purpose of the Study:
- To review the pleiotropic activities of PML in cytokine-induced signaling.
- To elucidate the role of PML in immune response, inflammation, and cytokine-induced apoptosis.
Main Methods:
- Literature review of current research on PML protein and cytokine signaling.
- Analysis of studies investigating PML's interactions and functions in cellular processes.
- Synthesis of findings on PML's role in immune and inflammatory pathways.
Main Results:
- PML protein exhibits diverse functions through interactions in the cytoplasm and nucleus.
- PML acts as a key regulator of cytokine signaling pathways.
- PML influences immune responses, inflammation, and apoptosis induced by cytokines.
Conclusions:
- PML protein has multifaceted roles beyond tumor suppression, notably in regulating cytokine signaling.
- Understanding PML's involvement in cytokine signaling opens new avenues for research in immunology and inflammation.
- PML protein is a critical mediator of cellular responses to cytokine-induced stimuli.
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