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Celiac disease screening in Brazilian patients with osteoporosis
Luiza Gusso1, Mariana Cionek Simões1, Thelma L Skare1
1Rheumatology Unit, Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brazil.
Objective:
To analyze if it is worthwhile to screen Brazilian osteoporotic patients for celiac disease (CD).
Subjects And Methods:
One hundred patients with osteoporosis and 97 controls were evaluated for IgA-EmA (IgA anti-endomysial antibodies) by indirect immunofluorescence method and IgG-anti-tTG (tissue transglutaminase) by ELISA assay. Positive patients were invited to have gastrointestinal endoscopy with jejunal biopsy.
Results:
Two patients had positive IgG-anti-tTG test and one of them also showed positive IgA-EmA. Only the latter had a positive duodenal biopsy for CD. None of the controls were positive for either auto-antibodies.
Conclusion:
We observed low prevalence of CD in osteoporotic Brazilian patients. This finding does not support routine screening for CD in patients with osteoporosis in our geographic region.
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