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Peripheral Artery Disease I: Introduction01:30

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy
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Does pernio cause nail dystrophy?

Pinar Ozuguz, Seval Dogruk Kacar, Semsettin Karaca

    JPMA. the Journal of the Pakistan Medical Association
    |May 29, 2014
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    Summary
    This summary is machine-generated.

    Pernio, an inflammatory response to cold, can cause painful skin lesions. This case report highlights the first instance of nail deformities linked to pernio, suggesting new clinical considerations for this condition.

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    Area of Science:

    • Dermatology
    • Pathology

    Background:

    • Pernio is an inflammatory condition triggered by cold and moisture, typically presenting as painful, itchy skin lesions on extremities.
    • While common, pernio has not been previously associated with nail deformities in medical literature.

    Observation:

    • This report details a case of pernio in a patient who developed significant nail deformities.
    • The nail changes occurred following prolonged exposure to cold, alongside other contributing factors.

    Findings:

    • The case demonstrates a novel association between pernio and acquired nail deformities.
    • This suggests that persistent inflammatory responses to cold can affect nail structure.

    Implications:

    • This finding expands the known clinical spectrum of pernio.
    • It highlights the importance of considering nail health in patients with recurrent or severe pernio, especially after cold exposure.