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Megavolume autologous fat transfer: part II. Practice and techniques.
Roger K Khouri1, Gino Rigotti, Eufemiano Cardoso
1Miami, Fla.; Verona, Italy; Ann Arbor, Mich.; and Houston, Texas From the Miami Breast Center; the Herbert Wertheim College of Medicine at Florida International University; the University of Verona; and the University of Michigan Medical School; Baylor College of Medicine.
Plastic and Reconstructive Surgery
|May 29, 2014
Summary
This study details a fat grafting technique for significant breast augmentation using autologous fat. The method ensures substantial long-term volume retention in over 1000 patients.
Area of Science:
- Plastic Surgery
- Regenerative Medicine
- Biotechnology
Background:
- Autologous fat grafting is a widely used technique for soft tissue augmentation.
- Achieving substantial and durable volume in breast augmentation via fat grafting presents challenges.
- Novel techniques are needed to optimize fat graft survival and volume retention.
Purpose of the Study:
- To describe a refined technique for megavolume autologous fat grafting to the breast.
- To evaluate the efficacy and long-term outcomes of this technique in a large patient cohort.
Main Methods:
- Utilizing the Brava external volume expansion device preoperatively to enhance recipient site vascularity and volume.
- Employing low-pressure liposuction and minimal centrifugation for gentle adipose tissue harvesting and purification.
- Implementing even and diffuse fat reinjection techniques to maximize graft-to-recipient interface and minimize interstitial fluid pressure.
- Using postoperative Brava device application as a protective, immobilizing splint for the grafted fat.
Main Results:
- Successful grafting of megavolumes (250-ml range) of autologous fat into the breasts.
- Demonstrated substantial long-term volume retention in over 1000 treated patients.
- The described techniques minimize trauma during fat harvesting and optimize graft integration.
Conclusions:
- The described technique, combining preoperative and postoperative Brava use with optimized fat harvesting and reinjection, enables successful megavolume breast augmentation.
- This approach leads to significant and durable volume retention, offering a viable option for breast augmentation.
- The technique has been safely and effectively applied in over 1000 patients, indicating its clinical utility.

