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A "light-up" and "spectrum-shift" response of aptamer-functionalized silver nanoclusters for intracellular mRNA
Jingjing Li1, Jia You, Yinping Zhuang
1Department of Radiology, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221006, China. xkpaper@163.com.
Chemical Communications (Cambridge, England)
|May 29, 2014
Abstract:
We have designed a novel multifunctional DNA scaffold for the synthesis of fluorescent silver nanoclusters (Ag NCs) using a one-pot approach. The obtained DNA/Ag NCs presented a "light-up" and "spectrum-shift" response to target DNA in vitro and could further image the tumor-related mRNA in living cells.
